Given that mutations of Nr2f2 are highly associated with CHDs (Al Turki et al., 2014), the expression of Nr2f2 is also confined to the ventral hippocampus in human embryos (Alzu’bi et al., 2017), and Nr2f2 gene is required for the distinct characteristics of the ventral hippocampus in mouse (Figures 1 and 4), we wondered whether CHD patients carrying mutations of Nr2f2 also display symptoms of psychiatric disorders, such as depression, anxiety, or schizophrenia, related to the ventral hippocampus. The gene discussed is NR2F2; the disease is major depressive disorder.