Since the ventral hippocampus participates in the regulation of emotion and stress, mutations in the Nr2f2 gene lead to CHDs, and the formation of the ventral hippocampus is disrupted in Nr2f2 mutant mice at 1M, we wondered whether CHD patients with Nr2f2 mutations also exhibit symptoms associated with psychiatric disorders such as depression, anxiety, or schizophrenia. This evidence concerns the gene NR2F2 and depressive disorder.