There are few existing resources for HCPs indicating best ways to optimize AID settings, which is why traditional insulin pump dosing guidelines are often still used.8 Further, other reports have suggested optimal settings for different AID systems that cannot be applied to CIQ due to differing tunable parameters.10,18,19 An implication of this report is that, for Control-IQ users, strengthening the Correction Factor may improve TIR without necessarily impacting hypoglycemia. This evidence concerns the gene INS and Hypoglycemia.