TREM2 and brain disorder: The TREM2 receptor has been connected to various pathophysiology in brain diseases such as dementia (Carmona et al., 2018; Edwin & Henjum, 2020; Gratuze et al., 2018; Ulland & Colonna, 2018; Wang et al., 2020; Zhao et al., 2022), and TREM2 signaling is involved in the regulation of critical microglial functions encompassing proliferation, cytokine release, survival and metabolism (Zhao et al., 2022).