Corrado et al. observed that SEVs from chronic myeloid leukemia cells could stimulate the expression of IL-8 in BM stromal cells, which further promoted the development of chronic myeloid leukemia through its receptors CXCR1 and CXCR2 [15]. Here, CXCR2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.