HNRNPA1 and HNRNPA2B1 have previously been reported to be associated with parental lifespan in human populations [25] and with senescence in human primary cells [24, 52], whereas HNRNPM and AKAP17A have previously been reported to demonstrate predictive associations with cognitive decline and loss of muscle strength [53, 54]. This evidence concerns the gene HNRNPA2B1 and Mental deterioration.