ERBB2 and neoplasm: Moreover, since 164/8-1B/H2N.luc + tumours in immunocompromised mice metastasize to the brain (Milsom et al. 2013), these results support our planned future studies to examine the effectiveness of [225Ac]Ac-DOTA-trastuzumab for RIT of HER2-positive BM in this mouse tumour xenograft model.