PSEN1 and ADan amyloidosis: Interestingly, but not surprisingly, when ADanPP mice were crossed with Aβ‐depositing APP‐PS1 TG mice, double‐TG ADanPP/APP‐PS1 mice exhibited a reduction in Aβ deposition compared with APP‐PS1 single‐TG littermates (Coomaraswamy et al, 2010), despite FDD patients showing co‐deposition of Aβ and ADan.