In FDD KI mice, the levels of mature BRI2 in critical cellular compartments, including synapses, are diminished due to the partial targeting of the FDD mutant BRI2 immature protein for Endoplasmic Reticulum‐associated degradation (ERAD; Yin et al, 2021a, 2021b). The gene discussed is ITM2B; the disease is ADan amyloidosis.