On the contrary, depletingHSP90B1 in the radioresistant GBM cell lines, as well as MGG8, a type of GSCs that is innately resistance to radiotherapy, impaired repair of IR-induced DNA damage as evidenced by prolonged levels of γ-H2AX (Fig. 2B) and longer-lived γ-H2AX positive foci (Fig. 2C andSupplementary Fig. 3C [available online]). This evidence concerns the gene H2AX and glioblastoma.