Furthermore, nuclear FGFR1, interacting with RNA‐Polymerase II (Pol II) and forkhead box protein A1 (FOXA1), regulates the transcription of target genes, which is a process independent of tyrosine kinase activity and mediates resistance of ER+ breast cancer cells to estrogen inhibitors and fulvestrant.142. The gene discussed is FGFR1; the disease is breast carcinoma.