SOX9, which is stimulated by the Wnt/β‐catenin pathway, enhances the transcription and expression of FGF7 and FGFR2, thereby stimulating the downstream pathway of FGFR2 to promote the proliferation of cholangiocarcinoma cells and resistance to pemigatinib.203. This evidence concerns the gene FGFR2 and cholangiocarcinoma.