In bladder cancer, tweety family member 3 inhibits phosphorylation of FGFR1 and downregulates the H‐Ras/A‐Raf/MEK/ERK signaling pathway (downstream targets include c‐Jun and c‐Fos) to inhibit the invasion and migration of bladder cancer cells.175. The gene discussed is JUN; the disease is urinary bladder cancer.