Our current study indeed verified the expression of GPR65 in IECs and its functionality in IBD, further broadening the understanding of the role of epithelial GPR65.22 GPR65-mediated innate defense responses, including the production of AMPs in IECs, unequivocally clarify an attractive mechanism for therapeutic exploitation, notwithstanding some contextual discrepancies outlined above with respect to the capacity of GPR65 to affect the progression of colitis and CAC. The gene discussed is GPR65; the disease is colitis.