NPHS2 and focal segmental glomerulosclerosis: To investigate the role of Btg2 in ADR‐induced FSGS, we generated the podocyte‐specific Btg2 knockout mice by crossing the loxp‐flanked Btg2 mice (Btg2f/f) with the Nphs2‐Cre mice in which Cre recombinase is exclusively expressed in the podocyte (Figure2a).