In the first one, mice with endometrium‐specific deletion of p53 developed carcinomas representing all type II histological subtypes, including serous, clear cell, undifferentiated EEC and UCS.[19] In contrast in the second one, conditional deletion of endometrial p53 had no phenotype, and double p53 and Pten deletion mice caused invasive EECs, with no signs of UCS, clear cell or serous carcinomas. The gene discussed is PTEN; the disease is serous adenocarcinoma.