Recently, it has been reported that succinate metabolism plays an important role in various tumors.Tao et al. [42] reported that a decrease in SDHA/B(Succinate dehydrogenase subunit A/B) promotes HCC proliferation.SDHB silencing leads to increased levels of HIF-1α and adenosine monophosphate-activated protein kinase, which promotes ovarian cancer metastasis [43]. Here, HIF1A is linked to hepatocellular carcinoma.