The top 20 up-regulated metabolites (including perseitol, meloxicam, PFAP-PAP, camalexin, rhodinyl acetate, diclofenac, etc. The top 20 down-regulated metabolites (including propachlorEsa, naringin, camptothecin, pantothenic acid, and succinic acid, etc. were shown by multiplicity of differences in Fig. 6C. KEGG pathway analysis showed that these differential metabolites were mainly focused on the CAMP signaling pathway, Central carbon metabolism in cancer, Oxidative phosphorylation and Citrate cycle (TCA cycle), etc. (Fig. 6D-E). This evidence concerns the gene CAMP and cancer.