BBC3 and rheumatoid arthritis: Moreover, pro-apoptotic genes BCL2 like 1 (BCL2L1, also known as BCLXL) and BCL2-binding component 3 (BBC3, also known as PUMA) were upregulated by ST2825 in LPS-stimulated RA SFs, suggesting that ST2825 may relieve the apoptotic resistance of RA SFs.