In addition, our results showed that targeting MyD88 by ST2825 significantly inhibits p65-dependent NF-κB binding site reporter luciferase activity (Fig. 5B) and may have an additional effect by inactivating the IKK-related kinases TAK1 and TBK1, and NF-κB p65 in RA SFs treated with LPS (Fig. 5C and Additional file 1: Fig. S8). The gene discussed is MYD88; the disease is rheumatoid arthritis.