Anoikis, a distinct type of apoptosis that occurs in normal epithelial and endothelial cells, is also negatively regulated by FAK signaling In human breast cancer, the mechanism of FAK-induced cell resistance to anoikis was reported to be correlated with the increased activity of NF-kB, which is induced by the functional interaction between the N-terminal domain of FAK and TRAF2, a RING finger adaptor protein [65]. This evidence concerns the gene PTK2 and breast carcinoma.