Chemotherapy is often ineffective against ovarian cancer; however, the hyaluronic acid-labeled two-in-one drug delivery system HA-PLGA-NPs, containing paclitaxel and FAK siRNA, has high binding efficiency to CD44-positive tumor cells, resulting in increased cytotoxicity and apoptosis in drug-resistant tumors, as demonstrated in experimental studies [154]. This evidence concerns the gene PTK2 and ovarian cancer.