In skin squamous cell carcinoma, nuclear FAK was reported to interact with runt-related transcription factor 1 (Runx1) and recruit Runx1 regulatory proteins such as sin3a to inhibit the transcription of insulin-like growth factor binding protein 3, which induces cell cycle arrest at the G1 phase by suppressing the expression of cyclins and CDKs and increasing p21 expression [58]. This evidence concerns the gene PTK2 and skin squamous cell carcinoma.