As previously evidenced [20], HUMSCs delivery markedly altered the cytokines profile through downregulating the level of pro-inflammatory cytokines as well as upregulating the immunosuppressive cytokines in DSS-induced colitis, especially for the pro-inflammatory cytokine of IL-17A, IL-6, IL-1β and anti-inflammatory cytokine of IL-10, CCL5. The gene discussed is CCL5; the disease is colitis.