Indeed, in accordance with the correlation that occurs between PTX3 expression and tumor aggressiveness in BC patients (Fig. 1C), high PTX3 expressing MDA-MB-231 shNT and MDA-MB-468 PTX3 cells displayed a gene profile associated with high grade/more aggressive BC when compared to low PTX3 expressing MDA-MB-231 shPTX3 and MDA-MB-468 mock cells, respectively (Figure S5). The gene discussed is PTX3; the disease is breast cancer.