PTX3 and neoplasm: Together, these data indicate that the modulation of PTX3 levels in TNBC cells exerts a significant impact on tumor growth in vivo, high levels of PTX3 being associated with an elevated tumorigenic potential, as observed in human MDA-MB-231 shNT and MDA-MB-468 PTX3 tumors as well as in murine E0771 PTX3 tumors, whereas reduced levels of the protein confer a less aggressive phenotype, as observed in MDA-MB-231 shPTX3, MDA-MB-468 mock and E0771 mock tumors.