Consequently, the reduced expression of HIF-1α both at the mRNA and protein levels by our NIO/PX-YC is expected to decrease HIF-mediated vascular and metabolic genes (e.g., VEGF and the proton pump carbonic anhydrase 9), thus contributing to reduced angiogenesis and acidification of the tumoral milieu putatively leading to cancer cells’ growth arrest while further improving the delivery of drugs loaded into niosomes. Here, CA9 is linked to cancer.