MCM4 and Herpesviridae infectious disease: Mutations in GATA-2, which is required for NK cell maturation [152], hinder early differentiation of CD56bright NK cells, which predisposes individuals to herpesvirus infections and mutations in minichromosome maintenance complex component 4 (MCM4) or IRF8 inhibits the maturation of CD56dim NK cells, which makes individuals prone to EBV-associated lymphoproliferative diseases [153].