In this study, we evaluated the anti-HCC efficacy of MT and N-MT on the proliferation of Huh-7 and HepG2 liver cancer cell lines and compared the effect of N-MT and MT on the expression of miR-155-3p, SOCS2, PHLDA1, TP53, P21, BAX, and BCL-2 in the hepatocellular carcinoma cells. This evidence concerns the gene TP53 and hepatocellular carcinoma.