The proband carried a hemizygous frameshift deletion variant c.1876_1877del(p.Met626Valfs*22) in the FRMD7 gene on chromosome X and his mother was high myopia with the same heterozygous variant of the FRMD7 gene by Sanger sequencing (Fig. 4C) (Table 2), suggesting co-segregation of genotype and clinical phenotype (PP1_Supporting). The gene discussed is FRMD7; the disease is myopia.