AKT1 and neoplasm: Ginsenoside Rg5 [60, 61] and ginsenoside Rk1 [62, 63] have shown promising anti-tumor effects on MCF-7 cells by binding to active domains of PI3K proteins and increasing the levels of reactive oxygen species expression to inhibit PI3K/Akt signaling and via the extrinsic apoptotic pathway, intrinsic apoptotic pathway, and autophagic pathway.