Additionally, Rg3 [117] and Rh2 [118, 119] have been shown to regulate the methylation levels and demethylation levels of breast cancer-related genes and proteins, including TRMT1l, KDM5A, and CAS1, through mechanisms such as N6-adenylate methylation, thus altering the breast cancer-associated microenvironment, enhancing immunogenicity, and inhibiting cancer cell growth. The gene discussed is KDM5A; the disease is breast cancer.