CXCR4 is known to be overexpressed in more than 23 human cancers, and a negative correlation between CXCR4 expression and OS has been shown in non-small cell lung cancer, colorectal cancer, renal cell carcinoma, and acute myelogenous leukemia [18, 49–52]. The gene discussed is CXCR4; the disease is non-small cell lung carcinoma.