At the same time, the qRT-PCR results of this study showed that the expression of DDX24 in the sepsis group was significantly lower than that in the healthy group, so we speculated that it plays a protective role in the innate immune response in sepsis through negative regulation.DNA methyltransferases1(DNMT1) -mediated DNA methylation is involved in many human diseases by affecting many types of cellular processes, including cell growth, cell cycle progression, metastasis, apoptosis, development, and tumorigenesis [51]. This evidence concerns the gene DDX24 and Sepsis.