In addition, FHIT has been reported to increase mitochondrial calcium release and promote apoptosis [57].The mechanism of action of FTO, NUDT2 and FHIT in sepsis is not clear, and we speculate that FTO, NUDT2 and FHIT may promote the development of sepsis by participating in apoptosis, and the mechanism needs further study. The gene discussed is FHIT; the disease is Sepsis.