Many practice guidelines divide patients with stage II CRC into high-risk and low-risk groups according to different clinical and pathological characteristics, including perforation, obstruction, perineural invasion, lymphovascular invasion, poor differentiation, T4 lesions, harvesting less than 12 lymph nodes, positive margins, mucinous type, and high preoperative CEA levels. The gene discussed is CEACAM5; the disease is colorectal carcinoma.