In the current study of a population of patients with T2DM the additive impact of NAFLD on FMD was independent of all possible confounders including age, sex, smoking status, duration of diabetes, BMI, SBP, DBP, DLP, use of statin, use of insulin, FBS, HbA1C, TG, Cholestrol, HDL, and LDL. This evidence concerns the gene INS and diabetes mellitus.