Another study showed that compared to intratumoral radiomics alone, combining intratumoral and peritumoral 3 mm radiomic features significantly improved the predictive performance of EGFR mutation status in primary lung cancer (AUC = 0.730 vs. 0.774, p < 0.001), and in lung adenocarcinoma only (AUC = 0.687 vs. 0.630, p < 0.001) [22]. The gene discussed is EGFR; the disease is lung adenocarcinoma.