PARK7 and hepatocellular carcinoma: Also, the introduction of DJ-1 in TrkB knockdown cells recovered the expression of CSC markers (Figure S10A), and upregulation of both TrkB and DJ-1 markedly increases the levels of CSC markers relative to induction of TrkB or DJ-1 (Figure S10C), indicating that increasing CSC population via the inhibition of DJ-1 degradation by TrkB enhances the aggressiveness of HCC and maintenance of mesenchymal/SC state [25].