In addition, we previously noted that TrkB activates the IL6/JAK2/STAT3 signaling pathway in breast cancer via the formation of the TrkB/JAK2 complex and then induces the EMT program by upregulating Twist-1 [11], suggesting that DJ-1 and TrkB may orchestrate to activate the STAT3 signaling pathway. The gene discussed is IL6; the disease is breast carcinoma.