However, it remained possible that TrkB-mediated inhibition of DJ-1 degradation may activate the transition into highly aggressive HCC cells via induction of an epithelial–mesenchymal transition (EMT) program, which is associated with the acquisition of stem cell-like properties, invasive and metastatic capacity, anticancer drug resistance, and tumor relapse [41, 42]. This evidence concerns the gene PARK7 and hepatocellular carcinoma.