Recent studies emerged to indicate that Notum might be involved in progression of colorectal cancer (CRC), neonatal respiratory disease, oral squamous cell carcinoma (OSCC), and aberrantly expressed Notum was regulated by β-catenin/TCF, suggesting Notum functions as a potential new biomarker in CRC [14–18]. The gene discussed is NOTUM; the disease is oral cavity squamous cell carcinoma.