Further analysis suggested that the most powerful diagnostic panel combination of Notum and other 11 tumor markers received an AUC of 0.910, with sensitivity of 88.46% and specificity of 86.67%, which was higher than the combination of 11 tumor markers, with an AUC of 0.839 (Fig. 2d, Additional file 1: Fig. S3B). Here, NOTUM is linked to neoplasm.