As a key transcription factor, Sox2 protein stability, nuclear localization, and DNA regulation are determined by the PI3K/AKT/Sox2 signaling axis and directly modulate stemness, reprogramming, and cancer [48].Through functional experiments, we also identified that the stemness of GC was enforced by Sox2, as well as PI3K/AKT signaling pathway. Here, AKT1 is linked to gastric cancer.