HES1 and neoplasm: Compared to HES1 (−) tumors, expression levels of Ki67 (p = 0.0268) (Fig. 3B), RB1 (p = 0.0271) (Fig. 3C) and Cyclin D1 (p = 0.0487) (Fig. 3D) were all significantly upregulated in the HES1 (+) tumor cells.