TARDBP and amyotrophic lateral sclerosis: Transitions from liquid-like condensates to amyloids have been observed for peptides19,20, α-synuclein21, tau22,23 and a variety of RNA-binding proteins (RBPs) associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia24,25, including transactive response DNA binding protein 43 (TDP-43) (ref. 26), fused in sarcoma (FUS)12 and heterogeneous nuclear ribonucleoprotein A1 and A2 (hnRNPA1/2) (refs. 13,27).