Mantaka et al. discussed association of ET-1 gene rs2071942 and rs5370 polymorphisms with primary biliary cirrhosis (PBC), showing that distribution of genotypes and alleles of both loci were not significantly different between controls and PBC patients, whereas rs2071942 allele A and rs5370 allele T were associated with stage of disease progression39. The gene discussed is EDN1; the disease is primary biliary cholangitis.