If the two inflammatory components (CCN3, IL-28B) were abnormally expressed in SLE patients and there is significant association of ET-1 and CCN3, ET-1 and IL-28B, in the future, we will conduct functional study to clarify how ET-1 contributes to SLE development, and whether ET-1 contributes to SLE development by regulating CCB3, IL-28B. The gene discussed is IFNL3; the disease is systemic lupus erythematosus.