Specifically, 32 genes were up-regulated (GZMA, AIM2, CASP5, GZMB, NOD2, NLRP7, GSDMC, PYCARD, GSDMB, NLRC4, CASP1, NLRP6, GSDMA, NLRP3, CASP4, NLRP1, BAX, IRF1, CHMP4A, L18, CASP8, GSDMD, NOD1, PLCG1, CASP3, GPX4, TP53, CHMP6, CHMP2A, IRF2, CHMP4B, HMGB1) and 9 genes were down-regulated (IL1B, CHMP3, CHMP4C, CHMP2B, IL1A, CASP9, CYCS, TP63, NLRP2) in ccRCC tissues. Here, IL1A is linked to nonpapillary renal cell carcinoma.