The purpose of the study is to analyze the genetic and transcriptional changes of pyroptosis-related genes (PRGs) in ccRCC, identify pyroptosis-related subtypes, analyze the clinical and microenvironmental differences among different subtypes, develop a corresponding prognostic model, and interpret the effect of pyroptosis on ccRCC microenvironment. Here, GART is linked to nonpapillary renal cell carcinoma.