Specifically, 32 genes were up-regulated (GZMA, AIM2, CASP5, GZMB, NOD2, NLRP7, GSDMC, PYCARD, GSDMB, NLRC4, CASP1, NLRP6, GSDMA, NLRP3, CASP4, NLRP1, BAX, IRF1, CHMP4A, L18, CASP8, GSDMD, NOD1, PLCG1, CASP3, GPX4, TP53, CHMP6, CHMP2A, IRF2, CHMP4B, HMGB1) and 9 genes were down-regulated (IL1B, CHMP3, CHMP4C, CHMP2B, IL1A, CASP9, CYCS, TP63, NLRP2) in ccRCC tissues. Here, CHMP2B is linked to nonpapillary renal cell carcinoma.