Specifically, 32 genes were up-regulated (GZMA, AIM2, CASP5, GZMB, NOD2, NLRP7, GSDMC, PYCARD, GSDMB, NLRC4, CASP1, NLRP6, GSDMA, NLRP3, CASP4, NLRP1, BAX, IRF1, CHMP4A, L18, CASP8, GSDMD, NOD1, PLCG1, CASP3, GPX4, TP53, CHMP6, CHMP2A, IRF2, CHMP4B, HMGB1) and 9 genes were down-regulated (IL1B, CHMP3, CHMP4C, CHMP2B, IL1A, CASP9, CYCS, TP63, NLRP2) in ccRCC tissues. Here, NLRP2 is linked to nonpapillary renal cell carcinoma.