Specifically, 32 genes were up-regulated (GZMA, AIM2, CASP5, GZMB, NOD2, NLRP7, GSDMC, PYCARD, GSDMB, NLRC4, CASP1, NLRP6, GSDMA, NLRP3, CASP4, NLRP1, BAX, IRF1, CHMP4A, L18, CASP8, GSDMD, NOD1, PLCG1, CASP3, GPX4, TP53, CHMP6, CHMP2A, IRF2, CHMP4B, HMGB1) and 9 genes were down-regulated (IL1B, CHMP3, CHMP4C, CHMP2B, IL1A, CASP9, CYCS, TP63, NLRP2) in ccRCC tissues. Here, GZMA is linked to nonpapillary renal cell carcinoma.