Such reduction of α-synuclein could help protect against the pathogenesis of Parkinson disease and other α-synucleinopathies.20 Additionally, increased expression of a specific transcript variant of Nedd4 due to a single-nucleotide polymorphism common in certain populations has been associated with a heightened risk of the development of keloid scar formation through its downstream influence in activating the NF-κB signaling pathways21,22. Here, NEDD4 is linked to Parkinson disease.