Collectively, these series of results provided strong and direct evidence that the risk C allele of rs4810856 functions as an allele-specific enhancer to provoke the expression of PREX1, CSE1L or STAU1 through ZEB1-mediated long-range enhancer-promoter interactions, ultimately contributing to the proliferation of CRC cells. Here, STAU1 is linked to colorectal carcinoma.