Therefore, we performed in-depth analysis using LD score regression (LDSC) to assess the proportion of ABC variants associated with heritability for each cancer type, and observed that ABC variants could explain a significant fraction of cancer heritability, ranging from 0.5% in thyroid carcinoma (THCA) to 12% in prostate adenocarcinoma (PRAD, Fig. 2e). This evidence concerns the gene ABCB6 and cancer.