Collectively, these findings provided strong evidence that PREX1, CSE1L and STAU1 play crucial roles in CRC tumorigenesis via synergistically activating p-AKT signaling pathways, implying that a complex network of multiple causative genes is responsible for tumorigenesis of CRC and hopeful to server as targets with therapeutic potential in future. The gene discussed is PREX1; the disease is colorectal carcinoma.