In addition, we applied ABC strategy to construct enhancer-gene regulatory maps in CRC tissues and identified an ABC variant rs4810856 could contribute to CRC risk by facilitating a long-range chromatin interaction to promote the expression levels of PREX1, CSE1L and STAU1, which synergistically activate p-AKT signaling pathway to drive CRC tumorigenesis. Here, CSE1L is linked to colorectal carcinoma.