CALCA and infection: Furthermore, since Calca was found to be predominantly high throughout DPA neurons compared to other neurotransmitters and peptides involved in pain transmission (Fig. 2e and Fig. S3e, f), CGRP therapeutics for primary headache disorders may be beneficial for cases of intractable dental pain,61 although the impact of such therapeutics on concomitant infection and beneficial inflammation will need to be carefully examined.