To this end, we compared the ratio of the canonical effector molecules of NOTCH1 that were expressed in the tumours (HEYL, HEY1, HEY2, HES1, HES4, HES5)25 over NRARP. We found a significant increase (Wilcoxon rank-sum test; p-values detailed in figure) in tumour versus normal cells for all targets in both tumours, with the exception of HES4 in nuclei derived from one of the tumours (Fig. 3c). The gene discussed is HES4; the disease is neoplasm.