Although NOTCH1 has not been directly implicated as a driver of reninoma, somatic fusion events in NOTCH1 and its paralogues, NOTCH2 and NOTCH3, have been reported to underpin glomus tumours, which are neoplasms arising from glomus bodies (typically in nail beds) and which are histological mimics of reninoma11. The gene discussed is NOTCH1; the disease is neoplasm.