HEY1 and neoplasm: To this end, we compared the ratio of the canonical effector molecules of NOTCH1 that were expressed in the tumours (HEYL, HEY1, HEY2, HES1, HES4, HES5)25 over NRARP. We found a significant increase (Wilcoxon rank-sum test; p-values detailed in figure) in tumour versus normal cells for all targets in both tumours, with the exception of HES4 in nuclei derived from one of the tumours (Fig. 3c).