Finally, we compared NOTCH1 expression between both reninoma data sets and bulk transcriptomes from congenital mesoblastic nephroma (n = 21), Wilms tumour (n = 308), renal cell carcinoma (RCC, n = 824) and normal kidneys (n = 332) and found significant overexpression of NOTCH1 in reninomas26–30 (Wilcoxon rank-sum test, p < 0.05; Fig. 4c). This evidence concerns the gene NOTCH1 and mesoblastic nephroma.