ALDH2 and obesity due to melanocortin 4 receptor deficiency: To assess the effect of the East Asian-specific ALDH2 Glu504Lys mutation on diet-induced obesity and related metabolic traits, Aldh2 KI, HE, and WT mice were placed on high-fat high-sucrose diet (HFHSD) for 24 weeks since the age of 4 weeks.