Aldh2 KI and HE mice also had significantly higher hepatic triglycerides contents and more severe hepatic steatosis than the WT mice on HFHSD (0.32 ± 0.05 vs, 0.21 ± 0.03 vs. 0.19 ± 0.03 mg/mg liver tissue, P-for-trend = 0.034) (Fig. 1g, j) at the age of 24 weeks. This evidence concerns the gene ALDH2 and fatty liver disease.