However, Aldh2 KI and HE mice showed dose-dependently increase in serum leptin levels (11.13 ± 2.13 vs. 7.21 ± 0.97vs.3.24 ± 0.39 mg/ml, P-for-trend = 0.0002, Fig. 2m), increase in free fatty acid levels (0.92 ± 0.040 vs. 1.08 ± 0.05 vs. 0.83 ± 0.05 mEq/L P-for-trend = 0.012, Fig. 2n), decrease in serum adiponectin levels (7832.7 ± 106.4 vs. 8539.8 ± 312.4 vs. 9115.6 ± 356.9 ng/ml, P-for-trend = 0.0032 Fig. 2o), and increase ethanol levels (0.63 ± 0.09 vs. 0.40 ± 0.06 vs. 0.34 ± 0.07 mEq/L P-for-trend = 0.0008, Fig. 2p) compared with WT mice. This evidence concerns the gene ADIPOQ and hereditary elliptocytosis.