Body composition analysis revealed significantly increased fat mass of Aldh2 KI and HE compared with the WT mice fed on HFHSD (12.40 ± 1.00, 10.04 ± 1.09, 8.41 ± 0.78 g, P-for-trend = 0.0058) (Fig. 1c) at the age of 24 weeks. Here, ALDH2 is linked to hereditary elliptocytosis.