In line with the present results, Alda-1, a prototype of the ALDH2 activator has been shown to alleviate nonalcoholic hepatic steatosis in apolipoprotein E-knockout mice48 and reversed alcohol-induced hepatic steatosis in animals49, supporting activation of ALDH2 also prevents both alcohol and non-alcoholic hepatic steatosis. The gene discussed is APOE; the disease is fatty liver disease.