Aldh2 KI, HE, and WT mice fed on HFHSD also had more white fat, including perigonadal fat (2.76 ± 0.27 vs. 2.41 ± 0.16 vs. 1.63 ± 0.13 g, P-for-trend < 0.001), inguinal fat (1.69 ± 0.16 vs. 1.55 ± 0.12 vs. 1.24 ± 0.11 g, P-for-trend = 0.011), mesenteric fat (0.85 ± 0.09 vs. 0.87 ± 0.05 vs. 0.32 ± 0.05 g, P-for-trend = 0.018), and a trend of increased liver weight (1.84 ± 0.07 vs. 1.70 ± 0.13 g vs. 1.61 ± 0.07 g, P-for-trend = 0.069), but less brown adipose tissue (BAT) weight (0.12 ± 0.009 vs. 0.17 ± 0.0.02 vs. 0.17 ± 0.01 g, P-for-trend = 0.006) (Fig. 1b) at the age of 24 weeks. This evidence concerns the gene ALDH2 and hereditary elliptocytosis.