The single lead variant associated with Lewy body dementia (19_44908684_T_C, rs429358) is part of cluster 21 that is linked to APOE and involves 9 age-related traits including age-related macular degeneration, Alzheimer’s disease, atherosclerosis, as well as longevity. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.