Although we have demonstrated the critical regulatory role of Repin1 in both iron overload and OVX-induced osteoporosis, we will conduct further studies on other osteoporosis models (such as senile osteoporosis, diabetic osteoporosis, etc.)in the future to find the universality of our conclusions and provide new insight into the general target of osteoporosis treatment. Here, REPIN1 is linked to osteoporosis.