PIK3CA and cancer: Several mutations that have been classified as cancer drivers in NSCLC were identified by ASCETIC as early alterations (see Supplementary Material Section 5, bottom panel) involved in the evolution of this cancer type: among them TP53, KRAS, KEAP1, CDKN2A, PIK3CA, ATM, EGFR, BRAF, KMT2D, EP300, and FBXWZ37.