SMCHD1 and muscular dystrophy: Our work on the D4Z4 2.5 mouse model also has limitations as this is the human D4Z4 array placed into the mouse context, where we know muscular dystrophy does not result, meaning this model is best interpreted in terms of the epigenetic regulation of D4Z4. In the future, it may be revealing to study the dynamic role of SMCHD1 at the chromatin to enhance our understanding of function beyond the snapshots provided here.