应用口服TPO-RA(海曲泊帕、艾曲泊帕、阿伐曲泊帕)治疗ITP时,如为低剂量爬坡(每日1片起始),减量时建议首先降低给药频次,逐渐延长给药间隔;如为高剂量起始(每日2~3片),减量时建议首先降低剂量(低剂量与原剂量交替应用),再减至低剂量持续应用,然后逐渐延长低剂量给药间隔。剂量调整期间,需密切监测血小板计数,尽量避免血小板过度升高或快速下降。. The gene discussed is TPO; the disease is autoimmune thrombocytopenic purpura.