Interestingly, mutations found in cluster 3.1 in KCNQ3 S4 (R227Q, R230C, and R236C) are known GoF gating mutations implicated in autism spectrum disorders (21, 22) (Table S2), indicating that cancers are selecting for mutations that increase KCNQ3 channel gating activity. Here, KCNQ3 is linked to cancer.