KCNQ1 and gastric adenocarcinoma: RNA expression analysis across our cohort (n = 897) finds that KCNQ1 is significantly down-regulated in OAC (P = 0.03) and slightly down-regulated in STAD (p = ns) and that KCNQ3 is significantly up-regulated at the RNA level in both oesophageal and gastric adenocarcinomas (OAC, P = 0.02; STAD, P < 0.001) (Fig 3A)—consistent with the patterns of amplification and deletion observed previously.