Missense mutations in our cohort are also under evolutionary selective pressure, and the most notable genes are KCNQ1, which generally is deleted and known to be a tumour suppressor in other cancers of the GI tract, and KCNQ3, which is under positive selective pressure in OAC, generally amplified, and on a known cancer susceptibility locus. The gene discussed is KCNQ3; the disease is cancer.