We chose to reduce the expression of KCNQ1 using a CRISPR/Cas9-induced knockout (KO) (Fig S4A) and overexpression (OE) KCNQ3 in oesophageal adenocarcinoma cell lines OE33 and FLO-1 (Fig S4B and C). Here, KCNQ1 is linked to esophageal adenocarcinoma.