Because of the co-occurrence of KCNQ3 and MYC amplification, it is difficult to distinguish between effects solely caused by an increased expression of KCNQ3 rather than an amplification of chr8q24, and so we chose to experimentally evaluate whether the expression of KCNQ genes can impact cancer cell phenotype in the most consistently associated cancer subtype—OAC. Here, KCNQ3 is linked to cancer.