Our restricted focus on these 3 CFs, containing 41 cells, at the expense of over 2400 other cells is one limitation of this work; our findings should not be interpreted as a broad analysis of the IgE repertoires of these subjects but rather as a deep characterization of convergent antibody evolution toward a key anaphylactic epitope driving peanut allergy. Here, IGHE is linked to peanut allergic reaction.