Alternatively, expression of the convergent antisense noncoding RNA in the INK4 locus at the CDKN2B locus in leukemia cell lines resulted in repression of CDKN2B mRNA expression through increased H3K9me2 and reduced H3K4me2 histone modifications at the CDKN2B promoter (24). This evidence concerns the gene CDKN2B and leukemia.