To this end, a recent report by Zheng et al, demonstrated that HIF1A-AS3 locus does produce 659 nucleotides long spliced HIF1A anti-sense lncRNA, HIFAL, in breast cancer cells which induces HIF1A trans-activation through recruitment of prolyl hydroxylase 3 (63). The gene discussed is ENSG00000258667; the disease is breast carcinoma.