AbnormallyIOP blocks axoplasmic flow in the optic nerve, resulting in a lackof neurotrophic factors such as brain-driven neurotrophic factor (BDNF)or nerve growth factor (NGF) and oxygen supply becomes unwanted ischemia.These abnormal manifestations cause RGC dendrites to form dendriticarborization, resulting in potential visual field defects.111 IOP is the pressure exerted by AH and is determinedby the balance between the production of AH and excretion from theeye. Here, NGF is linked to ischemia.