Moreover, cytoplasmic localized TIAM1 (NES-TIAM1, resistant to siTIAM1#2) was no longer able to rescue the decrease in migration observed with TIAM1 knockdown (SI Appendix, Fig. S3 D–F), further supporting a role for nuclear TIAM1 in promoting NSCLC migration. This evidence concerns the gene TIAM1 and non-small cell lung carcinoma.