We found that colchicine could decrease the vascular inflammation (determined by IL-1β, IL-18 and TNF-α), oxidative stress (determined by NOX2 and NOX4) and cell pyroptosis (determined by NLRP3, ASC, cleaved caspase-1 and N-GSDMD) in AAA mice. Here, CASP1 is linked to triple-A syndrome.