C4A and periodontitis: We demonstrate that PG0352 can efficiently desialylate both human serum and individual complement factors, including C1q, C4, C5, FH, FI, C4bp, and IgG, highlighting its importance in complement evasion and its potential link to altering host immune homeostasis, both of which play a critical role in the pathogenesis of periodontitis and its association with systemic illnesses [2,64,69,83].